Point of care screening device for quick detection of intracranial hemorrhage

Non invasive Fully Automatic Portable

Clinical Need

Early detection of traumatic brain injury

Reference: BrainLine 2018, Managing Pain After Brain Injury, BrainLine, viewed on Apr 2020, Reference
Reference: Dewan M-C 2020, Estimating the global incidence of traumatic brain injury, Journal of Neurosurgery, viewed on Apr 2020, Reference

More than 50 million suffer from traumatic brain injury each year and 50%-90% of patients with mild traumatic brain injury go unidentified or undiagnosed[1,2]. No one purposely leaves a traumatic brain injury untreated. Unfortunately, it is hard to diagnose symptoms in the beginning and know what symptoms the patients may suffer. Also many of the symptoms with traumatic brain injury can be misdiagnosed for other symptoms[3]. This delays the detection, and hence the treatment. That is why traumatic brain injury is associated with a very mortality and disability rate. WHO predicts that TBI will be the leading cause of disability in the world by 2020.

Reference:

[1] CENTER-TBI 2020, Traumatic Brain Injury Fact sheets and Policy brief, European Brain Injury Consortium, viewed 09 Apr 2020, Reference

[2] Prince C, Bruhn M-E 2017, ‘Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology’, Brain Sciences, 7(8), pp 105, viewed 30 Apr 2020, Reference

[3] Brain Injury Law center 2020, UNTREATED TBI: WHAT ARE THE EFFECTS OF AN UNTREATED CONCUSSION?, viewed 09 Apr 2020, Reference

Technology

Deep brain spectroscopy to investigate the brain tissue in-vivo

The optical methods used for neuromonitoring are based on emission of near-infrared light (NIR) at the surface of the head and detection of remitted light at a distance of several centimeters. The emitted light undergoes two main processes: scattering and absorption. Scattering depends on the cellular structure of the tissue and leads to stochastic movement of photons in the medium, as described by diffusion theory. The strong scattering and good transparency of tissue layers of the head for NIR light result in sufficient re-emission of photons back to the surface to allow for detection of photons that penetrated the brain cortex. The absorption is mainly associated with the interaction of photons with chromophores in the tissue, including hemoglobin, water, lipids, and a variety of proteins (such as cytochrome c).

CEREBO®'s proprietary optoelectronic configuration deploying diffuse reflectance spectroscopy detects the presence of intracranial hemorrhage non invasively

Reference: Okada E 2013, Photon Migration in NIRS Brain Imaging, Application of Near Infrared Spectroscopy in Biomedicine, Vol 4, pp 37-58, viewed Apr 2020, Reference

Core Competencies

NIRS

Algorithms

Software

Hardware

CEREBO®'s novel application of near infrared spectroscopy makes it possible to detect intracranial hemorrhage non invasively. It is an established science that correlates optical density of near infrared light with hemoglobin concentration.

The advanced mathematics based algorithm eliminates the need of expert data interpretation. Hence the algorithm makes it usable by a common man with minimal usage training.

The self calibration and intuitive user interface makes the device very easy to use.

The miniaturized hardware is designed to bridge the limitations of traditional tools that are bulky, expensive, and need much greater infrastructure support like air conditioning to provide point-of-care detection that will assist in triaging suspected TBI patients in military, sports, and emergency or urgent care environments both in India and internationally.

Product Offers

CEREBO Value

Generates result for one patient
at a time

CEREBO Plus

Maintains history for 100 most recent patients

CEREBO Cloud

All the patients data available on cloud accessible via app and web application